姓名:柳爱华 教授 博士生导师
职务:无
电子邮箱:lunaliu123@126.com
研究方向:疾病的分子免疫机制研究
个人简介:
本人长期致力于细胞因子与疾病关系的分子机制研究,主要研究方向是结核病的分子免疫机制研究。其特色与优势是将基础医学和临床医学相结合,利用多学科、多层面、多模态的技术和方法,针对疾病的发生、发展与转归机制开展深入、系统的研究,为疾病的防治提供新思路和新方法。先后承担的科研项目共计二十余项;目前主持或主持完成国家级和省级科研项目6项。在国内外重要刊物上发表论文百余篇,其中近5年SCI收录和国际期刊发表论文26篇;科学出版社出版专著4部(《细胞因子与结核病》、《莱姆病:基础与临床》、《莱姆病发病机制研究》和《莱姆病机制与治疗研究》);获专利31余项,厅(局)成果奖共3项。
个人简历:
2018/10-至今, bat365在线平台, 基础医学院生物化学与分子生物学系, 教授,博导
2013/07-2018/09, 泰国宋卡王子大学, 生命科学院, 微生物专业,
博士
2012/10-2013/06, bat365在线平台, 基础医学院生物化学与分子生物学系, 教授,硕导
2011/07-2012/09, bat365在线平台, 基础医学院生物化学与分子生物学系, 教授
2006/09-2011/06, 昆明医学院, 生物化学, 硕士
2005/12-2006/08, bat365在线平台, 基础医学院生物化学与分子生物学系, 副教授
2003/06-2005/11, 美国耶鲁大学医学院,内科学,博士后
2002/11-2003/05, bat365在线平台, 基础医学院生物化学与分子生物学系, 副教授
1996/01-2002/10, 昆明医学院, 基础医学院生物化学教研室, 讲师1992/01-1995/12, 昆明市结核病防治院, 内二科, 主治医师
1988/07-1991/12, 云南省曲靖市卫生防疫站, 公共卫生科, 医师
1983/09-1988/06, 昆明医学院, 预防医学, 学士
承担科研项目情况:
一、国家级科研项目
1、国家自然科学基金地区项目,82160304,IL-32调控免疫细胞的Hippo通路促进iNOS生成NO抗结核作用的机制研究, 2022/01-2025/12,34万元,中标,主持
2、国家自然科学基金地区项目,81560596,异佛司可林抑制伯氏疏螺旋体膜蛋白BmpA诱发的促炎细胞因子风暴的机制研究, 2016/01-2019/12,50.4万元,已结题,主持
二、省部级科研项目
1、云南省科技厅-bat365在线平台联合专项自然科学基金重点项目,2014FA011,白介素32在继发性肺结核病病理过程中的作用机制的研究,2014/10-2017/09,40万元,已结题,主持
2、云南省科技厅-昆明医学院联合重点基金项目,2019FE001(-002),基于CRISPR-Cas9基因编辑技术的IL-32抗结核菌作用机制研究,2019/10-2022/10,40万元来自云南省科技厅,在研,主持
3、云南省科技厅-bat365在线平台联合专项自然科学基金一般项目,2012FB011,白细胞介素32(IL-32)在活动性肺结核病中的作用研究,2012/10-2015/09,10万元,已结题,主持
4、云南省科技厅-bat365在线平台联合专项自然科学基金一般项目,2010CD221,MIF基因启动子多态性与肺结核遗传易感性关系的研究,2010/10-2013/09,10万元,已结题,主持
5、云南省教育厅科学研究基金项目,08Y0240,巨噬细胞移动抑制因子的表达与结核病关系的研究,2008/01-2010/01,0.7万元,已结题,主持
6、云南公共卫生与疾病防控协同创新中心孵化项目,2014YNPHXT19,白介素32在继发性肺结核病病理过程中的作用机制研究,2014/06-2016/06,10万元,已结题,主持
7、云南公共卫生与疾病防控协同创新中心孵化项目,2016YNPHXT10,ddPCR结核病快速诊断方法的建立和应用,2016/07-2017/06,10万元,已结题,主持
代表性论著:
期刊论文:
2017年
1. Jiaru Yang#, Xinlin Han#, Aihua Liu*, Xiyuan Bai, Cuiping Xu, Fukai Bao*, Shi Feng, Lüyan Tao, Mingbiao Ma, Yun Peng. Use of Digital Droplet PCR to Detect Mycobacterium tuberculosis DNA in Whole Blood-Derived DNA Samples from Patients with Pulmonary and Extrapulmonary Tuberculosis. Frontiers in Cellular and Infection Microbiology, 2017,7:369.
2. Hua Zhao, Aihua Liu*, Yuhui Cui, Zhang Liang, Bingxue Li, Fukai Bao*. Borrelia burgdorferi basic membrane protein A could induce chemokine production in murine microglia cell line BV2. Microbial Pathogenesis, 2017-9-1(111), 174-181.
3. Jiaru Yang#, Xinlin Han#, Aihua Liu*, Fukai Bao*, Yun Peng, Lüyan Tao, Mingbiao Ma, Ruolan Bai, Xiting Dai. Chemokine CXC ligand 13 (CXCL13) in Cerebrospinal Fluid Can Be Used as an Early Diagnostic Biomarker for Lyme Neuroborreliosis: A Meta-Analysis. Journal of Interferon and Cytokine Research, 2017-10-3, 37 (10): 433-439.
4. Hua Zhao#, Aihua Liu#, Longqiang Shen, Cuiping Xu, Ziwei Zhu, Jiaru Yang, Xinlin Han, Fukai Bao*, Weimin Yang*. Isoforskolin downregulates proinflammatory responses induced by Borrelia burgdorferi basic membrane protein A. Experimental and Therapeutic Medicine, 2017, 14(6): 5974~5980.
2018年
1. Zhenyu Zhao, Lvyan Tao, Aihua Liu*, Mingbiao Ma, Haiyi Li, Hua Zhao, Jiaru Yang, Shiming Wang, Yirong Jin, Xian Shao And Fukai Bao*. NF?κB is a key modulator in the signaling pathway of Borrelia burgdorferi BmpA?induced inflammatory chemokines in murine microglia BV2 cells. Molecular Medicine Reports 2018, 17: 4953-4958.
2. Aihua Liu, Fukai Bao* and Supayang P. Voravuthikunchai*. CATT polymorphisms in MIF gene promoter is closely related to human pulmonary tuberculosis in a southwestern China population. International Journal of Immunopathology and Pharmacology. 2018, May; 32: 1-7.
3. Mingbiao Ma, Lvyan Tao, Aihua Liu*, Zhang Liang, Jiaru Yang, Yun Peng, Xiting Dai, Ruolan Bai, Zhenhua Ji, Miaomiao Jian, Fukai Bao*. Macrophage migration inhibitory factor-794 CATT microsatellite polymorphism and risk of tuberculosis, a meta-analysis. Bioscience Reports. 2018, May 17.
4. Yun Peng#, Zhang Liang#, Aihua Liu*, Erhua Li, Xiting Dai, Ruolan Bai, Zhenhua Ji, Miaomiao Jian, Mingbiao Ma, Lvyan Tao, Fukai Bao*, Feng Wang1, YunFeng Bi1, Zhe Ding, Abi Manzama-Esso. Borrelia burgdorferi basic membrane protein A stimulates murine macrophage to secrete specific chemokines. International Journal of Medical Sciences. 2018; 15(13): 1473-1479. doi: 10.7150/ijms.26657.
5. Haiyi Li#, Ruolan Bai1#, Zhenyu Zhao1, Lvyan Tao1, Mingbiao Ma1, Zhenhua Ji1, Miaomiao Jian1, Zhe Ding1, Xiting Dai1, Fukai Bao*,Aihua Liu1*. Application of droplet digital PCR to detect the pathogens of infectious diseases. Bioscience Reports, 2018; 38 BSR20181170. https://doi.org/10.1042/BSR20181170.
6. Xiting Dai, Ruolan Bai, Miaomiao Jian, Zhenhua Ji, Zhe Ding, Feng Wang, Yunfeng Bi, Abi Manzamaesso, Taigui Chen, Lisha Luo, Aihua Liu*, Fukai Bao*. Immunogenicity of different dosing schedules of the human live attenuate rotavirus vaccine (RV1) in infants and children a meta-analysis. Human Vaccines & Immunotherapeutics. https://doi.org/10.1080/21645515.2018.1537742
2019年
1. Hua Zhao#, Xiting Dai#, Xinlin Han#, Aihua Liu*, Fukai Bao*, Ruolan Bai, Zhenhua Ji, Miaomiao Jian, Zhe Ding, Manzama-Esso Abi, Taigui Chen, Lisha Luo, Mingbiao Ma, Lvyan Tao. Borrelia burgdorferi basic membrane protein A initiates proinflammatory chemokine storm in THP 1-derived macrophages via the receptors TLR1 and TLR2. Biomed Pharmacother. 2019;115:108874.
2. Feng Wang, Mingbiao Ma, Suyi Luo, Min Yan, Lvyan Tao, Aihua Liu*, Jiaru Yang, Yun Peng, Xiting Dai, Ruolan Bai, Zhenhua Ji, Miaomiao Jian, and Fukai Bao*. Seroprevalence of Tick-Borne Anaplasma phagocytophilum Infection in Healthy Adult Population and Patients with Acute Undifferentiated Fever from the Yunnan Province of China. Vector Borne Zoonotic Dis. 2019;19(8):576-581
3. Zhe Ding, Mingbiao Ma, Lvyan Tao, Yun Peng, Yuanyuan Han, Luyun Sun, Xiting Dai, Zhenhua Ji, Ruolan Bai, Miaomiao Jian, Taigui Chen, Lisha Luo, Feng Wang, Yunfeng Bi, Aihua Liu*, Fukai Bao*. Rhesus Brain Transcriptomic Landscape in an ex vivo Model of the Interaction of Live Borrelia Burgdorferi With Frontal Cortex Tissue Explants. Front Neurosci. 2019 Jun 28;13:651.
4. Zhenhua Ji#, Miaomiao Jian#, Taigui Chen, Lisha Luo, Lianbao Li, Xiting Dai, Ruolan Bai , Zhe Ding, Yunfeng Bi , Shiyuan Wen, Guozhong Zhou, Manzama-Esso Abi, Aihua Liu*, Fukai Bao*. Immunogenicity and Safety of the M72/AS01E Candidate Vaccine Against Tuberculosis: A Meta-Analysis. Front. Immunol. 2019;10:2089.
5. Ruolan Bai, Shuijing Chi, Xiaofei Li, Xiting Dai, Zhenhua Ji, Miaomiao Jian, Yunfeng Bi, Feng Wang, Zhe Ding, Lisha Luo, Taigui Chen, Aihua Liu*, Fukai Bao*. Genetic diversity and drug susceptibility patterns of the Mycobacterium tuberculosis complex in Yunnan, China. Bioscience Reports. 2019 May 31; 39(5).
6. Ruolan Bai, Luyan Tao, Bingxue Li, Aihua Liu*, Xiting Dai, Zhenhua Ji, Miaomiao Jian, Zhe Ding, Lisha Luo,Taigui Chen, Mingbiao Ma, Yun Peng, Fukai Bao*. Using cytometric bead arrays to detect cytokines in the serum of patients with different types of pulmonary tuberculosis. International Journal of Immunopathology and Pharmacology. DoI:10.1177/2058738419845176. 2019, 33:1-5.
2020年
1. Shiyuan Wen, Feng Wang, Zhenhua Ji , YingYi Pan, Miaomiao Jian,YunFeng Bi, Guozhong Zhou, Lisha Luo, Taigui Chen, Lianbao Li , Zhe Ding, Manzama-Esso Abi, Aihua Liu* and Fukai Bao*. Salp15, a Multifunctional Protein From Tick Saliva With Potential Pharmaceutical Effects. Frontiers in Immunology. 2020;10: 3067.
2. Zhe Ding, Luyun Sun, Yunfeng Bi, Yu Zhang, Peng Yue, Xin Xu, Wenjing Cao, Lisha Luo, Taigui Chen, Lianbao Li, Zhenhua Ji, Miaomiao Jian, Lihong Lu, Manzama-Esso Abi, Aihua Liu*, Fukai Bao*. Integrative Transcriptome and Proteome Analyses Provide New Insights Into the Interaction Between Live Borrelia burgdorferi and Frontal Cortex Explants of the Rhesus Brain. J Neuropathol Exp Neurol Vol. 79, No. 5, May 2020, pp. 518–529.
3. Manzama-Esso Abi, Zhenhua Ji, Miaomiao Jian, Xiting Dai, Ruolan Bai, Zhe Ding,
Lisha Luo, Taigui Chen, Feng Wang, Shiyuan Wen, Guozhong Zhou, Fukai Bao*, Aihua Liu*. Molecular Interactions During Borrelia burgdorferi Migration from the Vector to the Mammalian Nervous System. Current Protein and Peptide Science, 2020, Vol. 21.
4. Guozhong Zhou, Qingyi Luo, Shiqi Luo, Zhaowei Teng, Zhenhua Ji, Jiaru Yang, Feng Wang, Shiyuan Wen, Zhe Ding, Lianbao Li, Taigui Chen, Manzama-Esso Abi, Miaomiao Jian, Lisha Luo, Aihua Liu*, Fukai Bao*. Interferon-γ release assays or tuberculin skin test for detection and management of latent tuberculosis infection: a systematic review and meta-analysis. Lancet Infect Dis, 2020. 20: 1457-1469.
5. Yun Peng, Taigui Chen, Lisha Luo, Lianbao Li, Wenjing Cao, Xin Xu, Yu Zhang, Peng Yue, Xiting Dai, Zhenhua Ji, Miaomiao Jian, Ruolan Bai, Zhe Ding, Feng Wang, Shiyuan Wen, Guozhong Zhou, Jing Kong, Suyi Luo, Aihua Liu*, Fukai Bao*. Isoforskolin and Cucurbitacin IIa promote the expression of anti-inflammatory regulatory factor SIGIRR in human macrophages stimulated with Borrelia burgdorferi basic membrane protein A. International Immunopharmacology 88 (2020) 106914.
6. Feng Wang#; Min Yan#; Aihua Liu*; Taigui Chen; Lisha Luo; Lianbao Li; Zhaowei Teng; Bingxue Li; Zhenhua Ji; Miaomiao Jian; Zhe Ding; Shiyuan Wen; Yu Zhang; Peng Yue; Wenjing Cao; Xin Xu; Guozhong Zhou; Fukai Bao*; The Seroprevalence of Anaplasma phagocytophilum in global human populations: a systematic review and meta-analysis, Transboundary and Emergiong Diseases, 2020, 67: 2050-2064.
7. Jiaru Yang, Lisha Luo, Taigui Chen, Lianbao Li, Xin Xu, Yu Zhang, Wangjing Cao, Peng Yu, Fukai Bao*, Aihua Liu*. Efficacy and Safety of Antibiotics for Treatment of Scrub Typhus A Network Meta-analysis. JAMA Network Open.2020;3(8):e2014487.
2021年
1. Jing Kong, Shiyuan Wen, Wenjing Cao, Peng Yue, Xin Xu, Yu Zhang, Lisha Luo, Taigui Chen, Lianbao Li, Feng Wang, Jian Tao, Guozhong Zhou, Suyi Luo, Aihua Liu*, Fukai Bao*, Lung organoids, useful tools for investigating epithelial repair after lung injury, Stem Cell Research & Therapy ,(2021) 12:95.
2. Lianbao Li#, Lisha Luo#, Taigui Chen#, Wenjing Cao, Xin Xu, Yu Zhang, Peng Yue, Yuxin Fan, Jingjing Chen, Meixiao Liu, Mingbiao Ma, Lvyan Tao, Yun Peng, Yan Dong, Bingxue Li , Suyi Luo, Jing Kong, Guozhong Zhou, Shiyuan Wen, Aihua Liu*, Fukai Bao*. Proteomic Analysis of Rhesus Macaque Brain Explants Treated With Borrelia burgdorferi Identifies Host GAP-43 as a Potential Factor Associated With Lyme Neuroborreliosis, Frontiers in Cellular and Infection Microbiology,2021-6,11: :647662.
3. Zhe Ding,Luyun Sun,Cen Yang,Aihua Liu*,Fukai Bao*. Exploring the secrets of brain transcriptional regulation: developing methodologies, recent significant findings, and perspectives, Brain Structure and Function, 2021, 226:313–322.
其它:
一、专著:
1、2016-10《莱姆病:基础与临床》,宝福凯,柳爱华,第二主编16.6万字,科学出版社,ISBN 978-7-03-051501-8,地址:北京市东皇城根北街16号
2、2017-11《细胞因子与结核病》,柳爱华,宝福凯,李冰雪,第一主编30万字,编辑:朱华,科学出版社,ISBN 978-7-03-055154-2,地址:北京市东皇城根北街16号
3、2021-1《莱姆病发病机制研究》,宝福凯,柳爱华,梁张,第二主编23.1万字,科学出版社,ISBN 978-7-03-059627-7,地址:北京市东皇城根北街16号
4、2021-1《莱姆病机制与治疗研究》,宝福凯,柳爱华,李冰雪,第二主编25.8万字,科学出版社,ISBN 978-7-03-059628-4,地址:北京市东皇城根北街16号
二、专利:
2020年
1、国家实用新型专利:专利名称:一种蜱虫捕捉器。专利号:ZL 2019 2 0586148.6。发明人:宝福凯;潘颖颐;柳爱华;计震华;简苗苗;陈泰桂;罗丽莎;龙瑾庭。专利申请日:2019-4-26。专利权人:bat365在线平台。授权公告日:2020-1-24。发证单位:中华人民共和国国家知识产权局。
2、国家实用新型专利:专利名称:一种可移动伸缩加样枪。专利号:ZL 2019 2 1063249.1。发明人:柳爱华;罗丽莎;宝福凯;陈泰桂;简苗苗;计震华;李连保;丁喆;文世媛;周国忠;岳鹏;曹文静;张宇;徐鑫。专利申请日:2019-7-9。专利权人:bat365在线平台。授权公告日:2020-6-2。发证单位:中华人民共和国国家知识产权局。
3、国家实用新型专利:专利名称:一种用于RNA抽提过程中的EP管晾晒板体结构。专利号:ZL 2019 2 1451623.5。发明人:宝福凯;陈泰桂;柳爱华;罗丽莎;李连保;计震华;简苗苗;丁喆;文世媛;周国忠;张宇;徐鑫;岳鹏;曹文静。专利申请日:2019-9-3。专利权人:bat365在线平台。授权公告日:2020-6-2。发证单位:中华人民共和国国家知识产权局。
4、国家实用新型专利:专利名称:一种可移动的细胞刮刀。专利号:ZL 2019 2 1212839.6。发明人:柳爱华;罗丽莎;宝福凯;陈泰桂;简苗苗;计震华;李连保;丁喆;文世媛;周国忠;岳鹏;曹文静;张宇;徐鑫。专利申请日:2019-7-30。专利权人:bat365在线平台。授权公告日:2020-7-7。发证单位:中华人民共和国国家知识产权局。
5、国家实用新型专利:专利名称:一种超声破碎的冰浴装置。专利号:ZL 2019 2 1085731.5。发明人:宝福凯;文世媛;柳爱华;周国忠;计震华;简苗苗;丁喆;陈泰桂;罗丽莎;李连保。专利申请日:2019-7-11。专利权人:bat365在线平台。授权公告日:2020-4-14。发证单位:中华人民共和国国家知识产权局。
6、国家实用新型专利:专利名称:一种自动细胞刮。专利号:ZL 2019 2 1212839.6。发明人:宝福凯;陈泰桂;柳爱华;罗丽莎;计震华;简苗苗;李连保;丁喆;文世媛;周国忠;张宇;徐鑫;岳鹏;曹文静。专利申请日:2019-7-22。专利权人:bat365在线平台。授权公告日:2020-7-24。发证单位:中华人民共和国国家知识产权局。
7、国家实用新型专利:专利名称:一种煮蛋白仪。专利号:ZL 2019 2 1316787.7。发明人:宝福凯;陈泰桂;柳爱华;罗丽莎;计震华;简苗苗;李连保;丁喆;文世媛;周国忠;张宇;徐鑫;岳鹏;曹文静。专利申请日:2019-8-14。专利权人:bat365在线平台。授权公告日:2020-8-11。发证单位:中华人民共和国国家知识产权局。
8、国家实用新型专利:专利名称:一种螺旋体活体计数装置。专利号:ZL 2019 2 2067556.3。发明人:宝福凯;李连保;柳爱华;陈泰桂;罗丽莎;徐鑫;曹文静;岳鹏;张宇;王峰。专利申请日:2019-11-26。专利权人:bat365在线平台。授权公告日:2020-9-1。发证单位:中华人民共和国国家知识产权局。
2021年
1、国家实用新型专利:专利名称:一种改进的液氮罐。专利号:ZL 2020 2 1365481.3。发明人:柳爱华;岳鹏;宝福凯;曹文静;徐鑫;张宇;罗丽莎;陈泰桂;李连保。专利申请日:2020-7-13。专利权人:bat365在线平台。授权公告日:2021-3-12。发证单位:中华人民共和国国家知识产权局。
2、国家实用新型专利:专利名称:一种螺纹式过滤柱。专利号:ZL 2020 2 1365776.0。发明人:柳爱华;岳鹏;宝福凯;曹文静;徐鑫;张宇;罗丽莎;陈泰桂;李连保。专利申请日:2020-7-13。专利权人:bat365在线平台。授权公告日:2021-4-13。发证单位:中华人民共和国国家知识产权局。
3、国家实用新型专利:专利名称:一种冰盒。专利号:ZL 2020 2 1417301.1。发明人:柳爱华;曹文静;宝福凯;岳鹏;张宇;徐鑫;文世媛;周国忠;孔璟;罗夙医。专利申请日:2020-7-17。专利权人:bat365在线平台。授权公告日:2021-3-2。发证单位:中华人民共和国国家知识产权局。
4、国家实用新型专利:专利名称:一种免染胶剥离器。专利号:ZL 2020 2 1447304.X。发明人:柳爱华;曹文静;宝福凯;岳鹏;张宇;徐鑫;文世媛;周国忠;罗夙医;孔璟。专利申请日:2020-7-21。专利权人:bat365在线平台。授权公告日:2021-3-23。发证单位:中华人民共和国国家知识产权局。