姓名:于明
学历:博士
专家类别:讲师,硕导
邮箱:yuming@kmmu.edu.cn
通讯地址:云南省昆明市呈贡区雨花街道春融西路1168号
邮编:650500
研究方向
毕业于中国科学院微生物所。在中国科学院微生物研究所分子病毒实验室就读博士学位期间,研究病毒的进入宿主细胞的机制。在英国主要从基因表达调节、蛋白降解和细胞凋亡等方面研究淋巴细胞白血病发生的分子机制。目前的研究方向为白血病的分子机制,研究癌基因在白血病中的发生发展机制。
主持科研项目
(1)云南省科技厅—bat365在线平台应用基础研究联合专项, ZNF521蛋白调控细胞周期促进白血病增殖分子机制研究, 2021-09 至 2024-09。
(2)国家自然科学基金,Pu.1调节原癌基因Evi3表达及致癌机理(项目编号:81460028),2015-01至2018-12。
(3)云南省科技厅—bat365在线平台应用基础研究联合专项,AML患者基因突变相关性分析,2013-10至2016-09。
(4)云南省科技厅面上项目,Pu.1蛋白调控原癌基因Evi3表达及其在白血病发生过程中的作用,2013-05至2016-04。
(5)第46批中华人民共和国教育部留学回国人员科研启动经费,JNK3蛋白在APP蛋白表达的调控机制, 2013-1至2015-12。
研究成果
1. 期刊论文
(1) Li Xue, Shulan Shi, Hongtao Lei, Zhen Zhang, Xin Tian1, Lijuan Qiu, Jiaolian Tang, Liyue Kui, Weiwei Nan, Xiaoyue Cao, Qiangming Sun, Ming Yu, Hongchao; Jiang Soluble Sema4D level is positively correlated with Sema4D expression in PBMCs and peripheral blast number in acute leukemia, Disease Marker, 2022, 2022:1384471. doi: 10.1155/2022/1384471. eCollection.
(2) Hongchao Jiang; Jiaolian Tang; Lijuan Qiu; Zhen Zhang; Shulan Shi; Li Xue; Liyue Kui; Tilong Huang; Weiwei Nan; Bailing Zhou; Canchun Zhao; Ming Yu; Qiangming Sun; Semaphorin 4D is a potential biomarker in pediatric leukemia and promotes leukemogenesis by activating PI3K/AKT and ERK signaling pathways, Oncology reports, 2021, 45(4).
(3) Ming Yu; Salma Al-Dallal; Latifa Al-Haj; Shiraj Panjwani; Akina S. McCartney; Sarah M. Edwards; Pooja Manjunath; Catherine Walker; Alexander Awgulewitsch; Kathryn E. Hentges; Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13, Genesis, 2016, 54(10): 519-533.
(4) Ming Yu; Feng-Ting Liu; Adrian C Newland; Li Jia; The alpha-5 helix of Bax is sensitive to ubiquitin-dependent degradation, Biochemical and Biophysical Research Communications, 2008, 371(1): 10-15.
(5) M-H Malcles, H-W Wang, A Koumi, Y-H Tsai, M Yu, A Godfrey, C Boshoff; Characterisation of the anti-apoptotic function of survivin-DeltaEx3 during TNFalpha-mediated cell death, British Journal of Cancer, 2007: 96(11):1659-66.doi: 10.1038/sj.bjc.6603768.
(6) Yu M; Wang EX; Liu YF; Cao DJ; Jin NY; Zhang CWH; Bartlam M; Rao ZH; Tien P; Gao GF; Six-helix bundle assembly and characterization of heptad repeat regions from the F protein of Newcastle disease virus, Journal of General Virology, 2002, 83(3): 623-629.
(7) Risley Michael D; Clowes Christopher; Yu Ming; Mitchell Karen; Hentges Kathryn E; The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development, Developmental Biology, 2010, 342(2): 146-156.
2. 奖励
(1)中国人群血液肿瘤患者IDH1、IDH2、DNMT3A基因突变发现及其致病机理研究与应用, 云南省科技厅, 科技进步奖, 2020(曾云; 张登峰; 杨金荣; 于明; 邹阳; 向国强; 王燕梅 ).