李杰
学历：理学博士
职称：助理研究员
邮箱：lijie@kmmu.edu.cn
通讯地址：云南省昆明市呈贡区雨花街道春融西路1168号
邮编：650500
课题组网站：http://biotrainee.vip:25164/LeeLab_demo/index.html
简历
2011.09 -2016.06,哈尔滨医科大学，生物信息科学与技术学院，学士
2016.09 -2019.06,哈尔滨医科大学，生物信息科学与技术学院，硕士
2019.09 - 2023.07,清华大学，医学院，博士
2023.08–至今，bat365在线平台,生物医学工程研究院,助理研究员
研究方向
近年来借助生物信息学与分子生物学的研究方法，深入研究了与人类复杂疾病相关的biomarker识别、cfDNA液体活检的临床应用、及基因多组学的分子机制。成功识别了肿瘤病人与健康个体之间的生物标志物差异，以及不同肿瘤组织来源的差异性。通过机器学习技术，构建了识别肿瘤病人及区分肿瘤来源的模型，进而实现了泛癌的无创早筛，为广大肿瘤患者带来福音。还为临床监控癌症复发、评估药物耐受性提供了新思路。如此，液体活检得以快速、方便地在临床实践中应用，为个体化精准医疗系统的研发提供了坚实的理论、算法及实验基础。
承担科研项目
1. 国家自然科学基金委员会,青年科学基金项目，82404091，基于cfDNA动态靶向识别乳腺癌复发风险及分子亚型的技术和应用研究，2025-01至2027-12，直接经费30万元；主持；
2. 国家自然科学基金委员会，专项项目，82141102，胰岛素瘤激素异常合成机制研究，2022-01至2024-12，直接经费250万元；参与；
研究成果（论文、专利、专著等）
主要工作
1. Xu C#, Xia P#, Li J#, Lewis KB, Ciombor KK, Wang L, Smith JJ, Beauchamp RD, Chen XS. Discovery and validation of a 10-gene predictive signature for response to adjuvant chemotherapy in stage II and III colon cancer. Cell Rep Med. 2024 Aug 20;5(8):101661. doi: 10.1016/j.xcrm.2024.101661. Epub 2024 Jul 25. PMID: 39059386.(IF=16.9)
2.Chen Y, Zheng Q, Wang H, Tang P, Deng L, Li P, Li H, Hou J,Li J*, Wang L*, Peng J*. Integrating transcriptomics and proteomics to analyze the immune microenvironment of cytomegalovirus associated ulcerative colitis and identify relevant biomarkers. BioData Min. 2024 Aug 27;17(1):26. doi: 10.1186/s13040-024-00382-0. PMID: 39192288; PMCID: PMC11348729.(IF=4.5)
3.Li J#, Chen J#, Sun X#, Yang H#, Sun K, Liu C, Wang Y, Xu M, Ji X, Zhang J, Wu X, Wang A, Fan B, Zhang X, Wu Y, Cui P, Peng J, Zhao Y, Wu W, Yu H, Bu Z, Ji J, Lan X. Uncovering chromatin accessibility and cancer diagnostic potential via cell-free DNA utilization. Sci Bull (Beijing). 2024 Apr 8:S2095-9273(24)00247-0. doi: 10.1016/j.scib.2024.04.013. Epub ahead of print. PMID: 38664094.(IF=20.6)
4.Xiaolu Zhang, Jingwei Li, Xun Lan, Jie Li. Cell‐free DNA‐associated multi‐feature applications in cancer diagnosis and treatment. Clin. Transl. Disc. 2024;4:e280. doi: 10.1002/ctd2.280.(IF=暂无)
5.Li J#, Sun X, Yang H, Chen J, Bu Z, Ji J, Lan X*;Integrated analysis toolkit for dissecting whole-genome-wide features of cell-free DNA.Clin Transl Med；2023 Mar;13(3):e1212. doi: 10.1002/ctm2.1212；(IF=11.492)
6.Huanhuan Pang#, Yisheng Jiang#, Jie Li#, Yushen Wang#, Meng Nie#, Nan Xiao, Shuo Wang, Zhihong Song, Fansen Ji,Yafei Chang, Yu Zheng, Ke Yao, LiAng Yao, Shao Li, Peng Li, Lei Song, Xun Lan, Zhiheng Xu, Zeping Hu. Pang H, Jiang Y, Li J, Wang Y, Nie M, Xiao N, Wang S, Song Z, Ji F, Chang Y, Zheng Y, Yao K, Yao L, Li S, Li P, Song L*, Lan X*, Xu Z*, Hu Z*. Aberrant NAD+ metabolism underlies Zika virus-induced microcephal；Nature Metabolism；2021 Aug;3(8):1109-1124. doi: 10.1038/s42255-021-00437-0. Epub 2021 Aug 12；(IF=20.8)
7. Chen J#, Sun Y#,Li J#, Lyu M#, Yuan L#, Sun J, Chen S, Hu C, Wei Q, Xu Z, Guo T, Cheng X. In-depth metaproteomics analysis of tongue coating for gastric cancer: a multicenter diagnostic research study.Microbiome. 2024 Jan 8;12(1):6. doi: 10.1186/s40168-023-01730-8. PMID: 38191439; PMCID: PMC10773145. (IF=16.837)
8.J Li#, W Wang#, P Xia#, L Wan#, L Zhang, L Yu, L Wang, X Chen*, Y Xiao*, C Xu*。Identification of a five-lncRNA signature for predicting the risk of tumor recurrence in patients with breast cancer；International journal of cancer；2018 Nov 1;143(9):2150-2160. doi: 10.1002/ijc.31573；(IF=7.396)
9.Jie Li, Xun Lan *. Perspective on new cell-free DNA technologies for early cancer detection；Cancer Biology & Medicine；2023 Aug 8:j.issn.2095-3941.2023.0159. doi: 10.20892/j.issn.2095-394；(IF=5.5)
10. J Li#, M Xu#, J Peng#, J Wang, Y Zhao, W Wu, X Lan*.Novel technologies in cfDNA analysis and potential utility in clinic；Chinese Journal of Cancer Research；2021 Dec 31;33(6):708-718. doi: 10.21147/j.issn.1000-9604.2021.06.07； (IF=5.894)
11. 发明人：蓝勋；季加孚；步召德；李杰；陈佳辉；孙克用；孙欣。一种基于cfDNA组学特性的癌症无创早筛方法（国家发明专利）。中国; ZL202110118814.5; 2022年7月19日。
其他工作
1. C Xu, R Qi, Y Ping, J Li, H Zhao, L Wang, MY Du, Y Xiao, X Li. Systemically identifying and prioritizing risk lncRNAs through integration of pan-cancer phenotype associations.Oncotarget. 8 (7), 12041.
2. 2. Chaohan Xu, Yanyan Ping, Hongying Zhao, Shangwei Ning, Peng Xia, Weida Wang, Linyun Wan,Jie Li, Li Zhang, Lei Yu, Yun Xiao. LncNetP, a systematical lncRNA prioritization approach based on ceRNA and disease phenotype association assumptions.Oncotarget. 8 (70), 114603.
3. 3. Shuyuan Wang, Peng Xia, Li Zhang, Lei Yu, Hui Liu, Qianqian Meng, Siyao Liu, Jie Li, Qian Song, Jie Wu, Weida Wang, Lei Yang, Yun Xiao, Chaohan Xu. Systematical identification of breast cancer related circular RNA modules for deciphering circRNA functions based on the non-negative matrix factorization algorithm.International journal of molecular sciences. 20 (4), 919.
4. Xianze Wang, Hao Chen, Rui Jiang, Xiafei Hong, Junya Peng, Wenyan Chen, Jialin Jiang,Jie Li, Dan Huang, Hongmei Dai, Wenze Wang, Junliang Lu, Yupei Zhao, Wenming Wu. Interleukin-17 Aactivates and synergizes with the notch signaling pathway in the progression of pancreatic ductal adenocarcinoma.Cancer Letters. 508, 1-12.
担任过Science Bulletin,Briefs in Bioinformatics, Frontiers in oncology, International journal of cancer审稿人。
