戴学勤
学历:博士
专家类别:讲师,硕士生导师,云南省“兴滇英才支持计划 ”青年人才
邮箱:daixueqin@kmmu.edu.cn
通讯地址:云南省昆明市呈贡区雨花街道春融西路1168号
邮编:650500
简历
2023年2月-至今,bat365在线平台,生物医学工程研究院,讲师
2017年9月-2023年1月,中国科学院昆明动物研究所,硕博连读,理学博士
2013年9月-2017年9月,云南师范大学,生命科学学院,理学学士
研究方向
肿瘤生物学;基因组不稳定;乳腺(癌)类器官
承担科研项目
(1)国家自然科学基金委员会,青年科学基金项目,82302957,小细胞肺癌ARID1A功能丢失与靶向PARP1的协同致死效应及机制研究,2024-01-01至2026-12-31,30万,在研,主持。
(2)云南省科技厅基础研究计划,面上项目,202301CF070110,微纳塑料促进乳腺癌转移的小鼠模型研究,2024-06-01至2027-05-31,10万,在研,主持。
(3)国家自然科学基金委员会,重点项目,E3泛素连接酶 BCA2调控乳腺发育和促乳腺癌进展的功能和机制研究及靶向策略探索,2025-01-01至2029-12-31,230万,在研,参与。
(4)云南省重大科技计划生物医药专项,202302AA310046,乳腺癌类器官库及靶向示踪诊疗技术平台建设和运用,2023-06至2026-05,2270万元,在研,子课题二项目执行负责人。
(5)云南省昆大细胞有限公司,横向项目,乳腺癌类器官用于临床精准医疗的技术研究,2023-12-01至2025-11-30,140万,在研,项目执行负责人。
研究成果(论文、专利、专著等)
1. Dai X, Wang X, Yang C, Huang M, Zhou Z, Qu Y, Cui X, Liu R#, and Chen C#. 2022. Human fibroblasts facilitate the generation of iPSCs-derived mammary-like organoids.Stem Cell Research & Therapy[J]. 13, 377. (IF-5y: 8.387)
2. Dai X, and Guo X#. 2021. Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations. Ageing Research Reviews[J]. 68, 101342. (IF-5y: 14.282)
3. Qiu B#*, Dai X*, Li P, Larsen R, Li R, Price A, Ding G, Texada M, Zhang X, and Zuo D, Gao Q, Jiang W, Wen T, Pontieri L, Guo C, Rewitz K, Li Q, Liu W, Boomsma J#, Zhang G#. 2022. Canalized gene expression during development mediates caste differentiation in ants.Nature Ecology & Evolution[J]. 6, 1753-1765. (IF-5y: 18.635)
4. Li, R*, Dai, X*, Zheng, J., Larsen, R. S., Qi, Y., Zhang, X., ... & Zhang, G#. 2024. Juvenile hormone as a key regulator for asymmetric caste differentiation in ants.Proceedings of the National Academy of Sciences, 121(46), e2406999121. (IF-5y: 9.58)
5. Guo X*, Dai X*, Ni J, Ma X, Xue J, and Wang X#. 2019. Geraniin Differentially Modulates Chromosome Stability of Colon Cancer and Noncancerous Cells by Oppositely Regulating their Spindle Assembly Checkpoint.Environmental and Molecular Mutagenesis[J]. 60, 254-268. (IF-5y: 3.892)
6. Guo X*, Dai X*, Wu X, Zhou T, Ni J, Xue J, and Wang X#. 2020a. Understanding the birth of rupture-prone and irreparable micronuclei.Chromosoma[J]. 129, 181-200. (IF-5y: 4.316)
7. Guo X*, Dai X*, Zhou T, Wang H, Ni J, Xue J, and Wang X. 2020b. Mosaic loss of human Y chromosome: what, how and why. Human Genetics[J]. 139, 421-446. (IF-5y: 6.099)
8. Guo, X, & Dai, X. 2024. A complex systems approach to mosaic loss of the Y chromosome. GeroScience, 1-21. (IF-5y: 5.3)
9. Li Q*, Wang M*, Zhang P*, Liu Y*, Guo Q, Zhu Y, Wen T,Dai X, Zhang X, Nagel M, Dethlefsen BH, Xie N, Zhao J, Jiang W, Han L, Wu L, Zhong W, Wang Z, Wei X, Dai W, Liu L, Xu X, Lu H, Yang H, Wang J, Boomsma JJ, Liu C#, Zhang G#, and Liu W# 2022. A single-cell transcriptomic atlas tracking the neural basis of division of labour in an ant superorganism. Nature Ecology & Evolution[J]. 6, 1191-1204. (IF-5y: 18.635)
10. Guo, Y*, Li, Y, Zhou, Z, Hou, L, Liu, W, Ren, W, Mi D, Sun J,Dai X, Wu Y, Cheng Z, Wu T, Luo Q, Tian C, Li F#, Yu Z#, Chen Y# & Chen, C#. 2024. Targeting PRMT5 through PROTAC for the treatment of triple-negative breast cancer. Journal of Experimental & Clinical Cancer Research, 43(1), 314. (IF-5y: 18.635) (IF-5y: 11.4)
11. Wang Y*, Zhang C*, Wang N*, Li Z*, Heller R*, Liu R*, Zhao Y*, Han J*, Pan X, Zheng Z,Dai X, Chen C, Dou M, Peng S, Chen X, Liu J, Li M, Wang K, Liu C, Lin Z, Chen L, Hao F, Zhu W, Song C, Zhao C, Zheng C, Wang J, Hu S, Li C, Yang H, Jiang L, Li G, Liu M, Sonstegard TS, Zhang G, Jiang Y#, Wang W#, and Qiu Q#. 2019. Genetic basis of ruminant headgear and rapid antler regeneration.Science[J]. 364, eaav6335. (IF-5y: 59.937)